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Estrone
Estrone is one of the three (Estrone,Estradiol, and Estriol) naturally occurring Estrogens. Estrone is produced primarily from androstenedione originating from the gonads or the adrenal cortex. In premenopausal women, more than 50% of the estrone is secreted by the ovaries. In prepubertal children, men, and non-supplemented post-menopausal women the major portion of estrone is derived from peripheral tissue conversion of androstenedione.
Interconversion of estrone and estradiol also occurs in peripheral tissue. Estrone is a primary estrogenic component of several pharmaceutical preparations, including those containing "conjugated" and "esterified estrogens.” In pre-menopausal women estrone levels generally parallel those of estradiol.
After menopause estrone levels increase, possibly due to increased conversion of androstenedione to estrone.
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