Vitamin B12 (also known as cobalamin) is a co-factor in many metabolic processes. Deficiency of this vitamin is associated with both anemia and various neurologic disorders. Humans are unable to synthesize B12. Failure of the gastrointestinal part of the B12 transport pathway is the culprit
causing B12 deficiency. This was reviewed in an article from Denmark published online 1 May 2012.
Calcium supplements may increase risk of heart attacks, and drugs known as bisphosphonates taken to prevent osteoporosis carry significant risks (jaw bone and femoral fractures).
On the other hand high intake of oral vitamin D3 safely protects against osteoporosis with daily intake of 4,000 to 8,000 IU’s or once per week dosage of vitamin D3. This provides well below reported toxic levels. Enough sun exposure to provide this would increase the risk of skin cancer – basal cell and melanoma. Sun screens with an SPF rating above 15 are now recommended for almost everyone, with reapplication every 2 hours while in the sun, which also blocks vitamin D absorption.
How much vitamin D should you take? The latest word is substantially higher than the paltry recommendation of 600 IU-s daily from the U. S. Institute of Medicine. Analyses from the University of California at San Diego by researchers regarded as the two vitamin D experts in the world report that daily intake of 4,000 to 8,000 IU-s is needed to reduce the risk of several major diseases – breast and colon cancer, multiple sclerosis, and Type I diabetes by about half. Taking up to 40,000 IU-s per day is unlikely to result in vitamin D toxicity. I recommend 50,000 units of D3-50 once per week.
According to an article in NUTRITION REPORTER quoting a study in the American Journal of Clinical Nutrition, 2010, abundant magnesium reduces the risk of cardiac death. Low magnesium can lead to leg and foot cramps that awake one at night. Regular magnesium supplementation, 200 mgm 3 times per week, is a good idea.
Chronic Kidney Disease (CKD) is considered an inflammatory state. An increase in fiber intake of 10 grams per day per patient was highly beneficial in a study at the University of Utah School of Medicine. The original article was in Kidney International, 81, 300306.
Low vitamin D levels are common and are linked to a number of risk factors for cardiovascular disease, new evidence suggests. Heart attacks and premature death also are connected with low levels. There is evidence that low vitamin D levels affect blood pressure, insulin resistance, and coronary artery disease. This is from USA Today, October 4, 2011.
Humans obtain most of their vitamin D (which is really a prohormone) from exposure of the skin to sunlight. Unfortunately this exposure also increases the risk of skin cancer. Even in latitudes with high sun exposure, vitamin D (especially vitamin D3) blood levels are not optimal and should be supplemented on a regular basis. In my experience, the best product available to accomplish this is over the counter vitamin D3-50. Once an optimal blood level of 60-80 has been achieved, maintenance dosage is one capsule per week.
No calcium supplements are needed or should be taken. You no longer need calcium with that dosage of Vitamin D3-50 (50,000 mg). It is overkill and could lead to kidney and gallstones. Magnesium, 200 mgm per day, is, however, recommended.
Diseases particularly affected by low vitamin D-s effect on the immune system are psoriasis, multiple sclerosis, and asthma, as well as dementia.
A growing list of health issues is related to Vitamin D deficiency. The latest is hypertension (high blood pressure). Those people in the lowest Vitamin D quartile are three times more likely to have hypertension as those in the highest quartile. Correcting the problem can best be done by taking Vitamin D3-50 twice per week until the blood level reaches 60-80. One capsule per week from then on keeps it there for life.
Seven milligrams of zinc daily for 10 weeks, in a study from the European Journal of Clinical Nutrition, produced significant reductions in anger and hostility, as well as in feelings of depression and dejection.
Vitamin C is a major regulator of cell behavior, as is stated in an article in Cell Stem Cell, 2010;6:71-79. It is the only substance that reprograms adult cells back into stem cells and also enhances cell survival.