Obesity Impairs Immune System

Obesity is associated with poor immune response to influenza vaccination in humans. 250,000 to 500,000 people die worldwide from flu each year. Two-thirds of the US adult population is overweight or obese. A study reported in the International Journal of Obesity this year and done at the University of North Carolina shows that obesity impairs the body-s immune response to influenza vaccine.

The Obesity Answer

There is evidence at present that the condition of being overweight is different from the condition of being obese. Being overweight is the result of taking in more calories than one expends. Obesity, on the other hand, is much more complex. (more…)

Provin Plan

At the present time there is much more emphasis, and hence research spending, on cell replacement and development (i.e., stem cell research) than on cell death, which may prove to be just as important or more so.

It is generally accepted that cell death is the consequence of either a passive, degenerative process called necrosis, or of an active process called apoptosis. Apoptosis is a complex process that is indicated as programmed cell death actively driven by the cell. Necrosis is a passive consequence of gross injury to the cell. The physiologic consequences of necrosis are very different from those of apoptosis and have vastly different implications for our health.

The causative agents which initiate these cell death cycles are a group of viruses named recombinant Adeno Associated viruses and known as rAA viruses. This family of viruses causes the usual sequence of DNA signals to messenger RNA to reverse itself leading to alteration of immune response in either a positive manner (over-response leads to autoimmune disease) or under-response which leads to wild overproliferation of cells in which the body loses that ability to control cell death (cancer).

The diagram on the next page indicates how knowledge already available to us can be used as the basis for treatment of both autoimmune disease and cancer. A combination of drugs plus dietary and exercise modification to combat chronic inflammation blocks the appropriate cycle of the diagram.

A list of potential disease states that can be ameliorated or cured with medications or preparations already available on the market in the United States (and many other countries as well) follows:

Arthritis, Lupus, Scleroderma, AIDS, Probably Avian Flu, Obesity, Diabetes, Metabolic Syndrome, Breast Cancer, Colon Cancer, Prostate Cancer, Stomach Cancer, Lung Cancer, or Pancreatic Cancer

Any reader of this web site should consider the possibility that if he or she suffers from one of these conditions, the solution may already be available.

Immune System

The immune system can malfunction in cither of two directions: apoplosis or necrosis.Cell death by necrosis does not alert the immune system to continuing danger. Cancer can ensue. Cell death by apoplisis can lead to a hyperimmune state known as autoimmune disease. A host of autoimmune discases such as diabetes, multiple sclerusis, and rheumatoid arthritis can ensue.

Once apoptosis ratcher than necrosis occurs, a vicious cricle begins and recurs over and over due to what is known as “bystander effect.” Molecular mimicry isn’t necessary. Any recombinant Adeno-Associated viruses can perpetuate the cycle once it is established. The body actually becomes more efficient with each cycle.

Lymphocytes kill the virus and the cell containing the virus either by:
1. Necrosis, whereby dead cells are engulfed be macrophader or
2. Apoptosis, in which the nucleoli are fragmented and extruded. These extruded fragments are sequences of amino acids known as prions. The prions send a danger signal to the immune system which restart the cycle.

The Provin Plan includes the following drugs and dietary supplements:

Treats Autoimmune Disease Only
1. Human Chorionic Gonadotropin (blocks TNF alpha)
2. DHEA Sulfate caps block cardiovaskular disease and remove arterial plaque
3. Omega 3 Fatty acids(Omacor) and Gamma Linolcic Acid
4. Slow release niacin (Niaspan), which produces vasodilatation and opens the blood brain barrier in multiple sclerosis; also modifies abnormal blood lipids by enhancing production of prostaglandins E1 and E3
5. Anti-inflammatories (Bromase)
6. Colloidal silver

Treats Both
1. Valtex brand of valacyclovir
2. Ultram ER brand name of tramadol
3. Acomplia
4. Low protein plant-based diet
5. Exercise

Treats Cancer Only
1. Aldara cream plus H base cream
2. TNF alpha (BCG vaccination)
3. Vitamin D3 (Calcitriol) induces apoptosis of cancer cells

These drugs are readily available in the United States with the exception of Acomplia which has not yet been released in this country but is available on the Internet. Therefore Phase I clinical studies of this hypothesis could be begun immediately either alone or in conjuction with standart cancer therapies such as surgery, radiation, and/or chemotherapy allowing comparison of cure rates without jeopardy to the patients in the trails.