The Mother of Hormones

What is DHEA and what does it do? Dehydroepiandrosterone is a hormone produced by the adrenal gland and the skin. It is a precursor for many other hormones (hence the title ‘Mother of All Hormones,’ which shifts the body-s metabolism from a catabolic one of breakdown and fat storage – to an anabolic one.

It has been shown to slow down the aging process in lab animals. DHEA is also known to improve the symptoms of lupus, and there is currently a pending FDA study for approval of this very function. The best source I have found is Twist 25.

DHEA Sulfate blood levels should be monitored periodically. Levels that are too high could cause acne in men or peach fuzz hirsutism in women.

Hormones Again

Reproductive factors and risk of esophageal and gastric cancer in the Million Women Study: Results of the study showed that postmenopausal women with lower hormone levels were at greater risk for both types of cancer. Breastfeeding history, age at menopause, and childbearing did not differ in those with cancer and without.

The Current Story of Steroid Hormones

LDL cholesterol is a 27 carbon atom molecule as is Delalutin.

Progesterone is a molecule containing 21 or fewer carbon atoms.

Progesterone and pregnenolone are 21 carbon atom molecules.

DHEA – known as the mother of all hormones- is a 19 carbon atom molecule, as are androstenedione and testosterone. These three compounds are called androgens.

Anastrozole, an aromatase inhibitor, used here stops conversion of androgens (19 carbon atom steroids) to estrogens, which are 18 carbon steroids (estradiol, estriol, and estrone).

Prescription transdermal estrogen or testosterone can be used daily. They fine tune sexual performance.

Hormones in Control

From Scientific American (HUFFINGTON POST): Hormones aren-t just for sex. They control everything from when we feel hungry to the timing of our heart beats. A new hormone is called irisin. It helps to turn white fat into more metabolically active brown fat, which burns more calories. Irisin prolongs the beneficial effects of exercising and therefore increases insulin sensitivity.

Questions Answered About DHEA

How to Use DHEA?

Why DHEA supplement cream works better than pills?

Is DHEA Safe?

Twist 25 DHEA cream is the highest quality most effective anti-aging and wellness product available.

Health2Go, Inc. hired a PhD chemist with 18 years experience formulating and compounding topical specially made creams to develop and test Twist 25 DHEA cream. The requirements were set very high. There were 17 versions of the cream considered to develop the best possible cream mix.

Twist 25 cream is a highly specialized custom engineered emulsion cream in a coconut oil base  that delivers pharmaceutical grade bio-identical DHEA by simply rubbing the cream onto thin hairless skin so that DHEA is available at the ideal place in the dermis for best absorption and metabolism.  The small particle size makes Twist 25 cream unique allowing for optimal delivery of DHEA and a long shelf life. Safety studies were done for 90 days. Study participants had no irritations or adverse reactions to the cream. So you can have confidence in Twist 25 DHEA supplement cream knowing Health2Go, Inc. only sells the best possible DHEA cream. It’s not the cheapest. It’s the best. It works.

Recent medical research studies show DHEA must be delivered to the body as a specially made cream rather than as a pill supplement. There are 3 key reasons for this.

Reason 1) When taken as a pill, orally ingested DHEA is destroyed by the “first-pass effect” of the liver. Basically, this means that because the molecule is too large it appears to be a foreign substance, the liver filters most of the effective DHEA out before it can do any good: and, what does end up getting into the bloodstream is DHEA-S (DHEA sulphate).

Reason 2) DHEA-S is not the same as DHEA. DHEA-S is a different pro-hormone and has different benefits than DHEA. New medical research shows DHEA-S is not converted by the body into DHEA. However, DHEA is converted into DHEA-S, but not the other way around.

Twist 25 does supplement DHEA instead rather than DHEA-S.

(Fabian Hammer, Sandra Subtil, Philipp Lux, Christiane Maser-Gluth, Paul M. Stewart, Bruno Allolio and Wiebke Arlt. No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulphate to DHEA: In Vivo and in Vitro Studies. Journal of Clinical Endochrinology and Metabolism Vol. 90, No. 6 3600-3605)

So the majority of research studies of “DHEA” administered via oral DHEA supplements and consequently showed little benefit to “DHEA”(Sulphate) were not testing DHEA with an effective method of administration.

DHEA must be delivered to the body properly as a specially made DHEA cream – Twist 25.

Reason 3) Medical research shows the human body metabolizes DHEA into other hormones in the skin (the dermis). The skin is where we make and use much of the DHEA we make. So Twist 25 cream actually provides what the body produces naturally (bio-identical DHEA) where we use it (in the skin).

(Labrie F, Belanger A, Belanger P, Berube R, Martel C, Cusan L, Gomez J, Candas B, et al. Metabolism of DHEA in Postmenopausal women following percutaneous administration. Journal of Steroid Biochemistry & Molecular Biology, 103 (Feb 2007) pp 178-188) www.ncbi.nlm.nih.gov/pubmed/17084625

(Labrie F, Belanger A, Cusan L, Candas L intraPhysiological Changes in Dehydroepiandrosterone Are Not Reflected by Serum Levels of Active Androgens and Estrogens But Their Metabolites: Intracrinology. Journal of Clinical Endocrinology and Metabolism. Vol. 82 No. 8, pgs 2403-2409)http://press.endocrine.org/dol/pdf/10.1210/jcem.82.8.4161

(Labrie F, Labrie C. DHEA and intracrinology at menopause, a positive choice for evolution of the human species.) www.ncbi.nlm.nih.gov/pubmed/23126249

DHEA must be delivered to the body properly as a specially made DHEA cream – Twist 25.

To know DHEA supplementation is safe think it through logically. DHEA is a naturally occurring pro-hormone. It is the most abundant pro-hormone in the body. DHEA is a base building block for hormones we produce. 50 hormones use DHEA as a precursor. The body makes DHEA and pregnenalone from cholesterol.

Why would something the body produces be harmful. No medical research studies of DHEA have shown any dangerous or harmful effects.

The goal should be to maintain levels of DHEA as when we are at our healthiest, “in our prime”. Normal levels of DHEA at age 25 are about 350 micrograms for women and 550 micrograms for men. Each pump press of Twist 25 DHEA cream provides about 20 MG DHEA. So women age 35 and up would benefit from using at least 1-2 pump presses per day; and men 2-3 pump presses per day unless otherwise directed by your physician. Testing levels regularly with a blood spot test is recommended to ensure optimum levels are maintained.

Go to www.twist25.com to learn more or http://store.twist25.com to order on line.

I am not compensated in any way for sales of Twist 25 cream. Please see my websites at www.abouthormones.org and dheafacts.com for my advice about current medical science.

Everything You Want to Know About Menopause

DefinitionMenopause is the permanent end of menstruation and fertility, defined as occurring 12 months after the last menstrual period. Menopause is a natural biological process, not a medical illness. Even so, the physical and emotional symptoms of menopause can disrupt your sleep, sap your energy and – at least indirectly -trigger feelings of sadness and loss. (more…)

Women's Health Initiative Study Revisited

In July, 2002, the first results of the Women’s Health Initiative were published in the national media. These apparently negative results hit the concept of hormone replacement (HRT) like a bombshell. As a result, half the women who were taking hormones in one way or another stopped them over the next year. This was an unfortunate outcome, and as more information about the study has emerged, not a well-reasoned one. So let us consider a more rational approach.

Armed with six hundred twenty eight million tax payer dollars, the National Institutes of Health began the recruiting in 1993 in 40 centers around the country of what became 161,809 postmenopausal women between ages 50 and 79 for a randomized, double-blind study which was to be completed in 2005. The object was to find out once and for all whether hormones (estrogen and progesterone) really did protect women from developing heart problems and other chronic diseases (osteoporosis, colon cancer, Alzheimer’s, etc.). The main evidence in support of HRT came from an ongoing study of more than 48,000 nurses, which in 1991 showed a 50% reduction in heart attack rates.

The Women’s Health Initiative contained two huge hurdles that, in retrospect, severely limited its usefulness. If the study had too many young women, it would take years for them to get old enough to generate enough “events” like heart attacks and fractures to provide a statistically meaningful analysis. Another problem was finding enough women willing to risk a placebo. Women with severe menopausal problems such as hot flashes and night sweats were specifically discouraged from participating in the study because they probably would know almost immediately whether they were getting a sugar pill instead of the real thing.

As a result, the study, at it’s inception, was designed to be a study primarily of older, geriatric women well past menopause and would include only a small portion of younger women (ages 50 to 54), most of whom did not suffer from severe menopausal problems. The average age of a woman in the WHI was 63; 67% were over the age of 60, and only 1,700 women were between the ages 50 to 54. How important is the timing of hormone replacement? The major rise of heart disease and osteoporosis seen in women occurs between 45 and 55. Once that damage is done, it cannot be reversed. Studies in monkeys show, for instance, that delayed hormone replacement does not protect against plaque build-up in arteries.

Another major source of concern with the WHI is that hormone substitution (Premarin, Provera, Prempro) was used rather than real hormone replacement with human estradiol and progesterone. Also, the route of administration was oral (tablets) rather than non-oral (transdermal or subdermal), resulting in a first pass effect through the liver, not a good thing. No blood levels of estrogen or progesterone were measured.

In August, just to complete the debacle, earlier heart data from the WHI was revised and showed that the initially reported 24% increase in heart risk was not really statistically significant.

Basing one’s decision as to whether to use hormone replacement should not be determined by one study, particurarly one as poorly conceived and carried out as the Women’s Health Initiative Study. It should be made in conjunction with the woman’s physician, preferably a board certified specialist in Gynocology, and the doctor’s advice should be based upon the results of numerous studies combined, not just one severely flawed analysis innacurately reported in the media.