The Mother of Hormones

What is DHEA and what does it do? Dehydroepiandrosterone is a hormone produced by the adrenal gland and the skin. It is a precursor for many other hormones (hence the title ‘Mother of All Hormones,’ which shifts the body-s metabolism from a catabolic one of breakdown and fat storage – to an anabolic one.

It has been shown to slow down the aging process in lab animals. DHEA is also known to improve the symptoms of lupus, and there is currently a pending FDA study for approval of this very function. The best source I have found is Twist 25.

DHEA Sulfate blood levels should be monitored periodically. Levels that are too high could cause acne in men or peach fuzz hirsutism in women.

The Current Story of Steroid Hormones

LDL cholesterol is a 27 carbon atom molecule as is Delalutin.

Progesterone is a molecule containing 21 or fewer carbon atoms.

Progesterone and pregnenolone are 21 carbon atom molecules.

DHEA – known as the mother of all hormones- is a 19 carbon atom molecule, as are androstenedione and testosterone. These three compounds are called androgens.

Anastrozole, an aromatase inhibitor, used here stops conversion of androgens (19 carbon atom steroids) to estrogens, which are 18 carbon steroids (estradiol, estriol, and estrone).

Prescription transdermal estrogen or testosterone can be used daily. They fine tune sexual performance.


Only testosterone corrects erectile dysfunction (ED). By the way, using compounded testosterone cream or testosterone subcutaneous pellets corrects both libido and ED.

Furthermore, using testosterone alone is not a good idea. It must be accompanied by DHEA to prevent shrinkage of the testicles, as well as testicular tumors, which DHEA (administered by subcutaneous pellets or Twist 25 cream, which has proven effective by laboratory tests to raise DHEA levels) does beautifully.


The best overall predictor of longevity is a blood test which evaluates DHEA sulfate to cortisol ratio. Ideal level to a for i a ratio of 10. The easiest way to achieve that ratio is to augment DHEA level rather than try to decrease cortisol. This is done with non-oral DHEA administration to avoid the first pass effect of the liver. Twice daily Twist 25 cream and/or subcutaneous DHEA pellets every 2.5 to 3 months does the job.

Questions Answered About DHEA

How to Use DHEA?

Why DHEA supplement cream works better than pills?

Is DHEA Safe?

Twist 25 DHEA cream is the highest quality most effective anti-aging and wellness product available.

Health2Go, Inc. hired a PhD chemist with 18 years experience formulating and compounding topical specially made creams to develop and test Twist 25 DHEA cream. The requirements were set very high. There were 17 versions of the cream considered to develop the best possible cream mix.

Twist 25 cream is a highly specialized custom engineered emulsion cream in a coconut oil base  that delivers pharmaceutical grade bio-identical DHEA by simply rubbing the cream onto thin hairless skin so that DHEA is available at the ideal place in the dermis for best absorption and metabolism.  The small particle size makes Twist 25 cream unique allowing for optimal delivery of DHEA and a long shelf life. Safety studies were done for 90 days. Study participants had no irritations or adverse reactions to the cream. So you can have confidence in Twist 25 DHEA supplement cream knowing Health2Go, Inc. only sells the best possible DHEA cream. It’s not the cheapest. It’s the best. It works.

Recent medical research studies show DHEA must be delivered to the body as a specially made cream rather than as a pill supplement. There are 3 key reasons for this.

Reason 1) When taken as a pill, orally ingested DHEA is destroyed by the “first-pass effect” of the liver. Basically, this means that because the molecule is too large it appears to be a foreign substance, the liver filters most of the effective DHEA out before it can do any good: and, what does end up getting into the bloodstream is DHEA-S (DHEA sulphate).

Reason 2) DHEA-S is not the same as DHEA. DHEA-S is a different pro-hormone and has different benefits than DHEA. New medical research shows DHEA-S is not converted by the body into DHEA. However, DHEA is converted into DHEA-S, but not the other way around.

Twist 25 does supplement DHEA instead rather than DHEA-S.

(Fabian Hammer, Sandra Subtil, Philipp Lux, Christiane Maser-Gluth, Paul M. Stewart, Bruno Allolio and Wiebke Arlt. No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulphate to DHEA: In Vivo and in Vitro Studies. Journal of Clinical Endochrinology and Metabolism Vol. 90, No. 6 3600-3605)

So the majority of research studies of “DHEA” administered via oral DHEA supplements and consequently showed little benefit to “DHEA”(Sulphate) were not testing DHEA with an effective method of administration.

DHEA must be delivered to the body properly as a specially made DHEA cream – Twist 25.

Reason 3) Medical research shows the human body metabolizes DHEA into other hormones in the skin (the dermis). The skin is where we make and use much of the DHEA we make. So Twist 25 cream actually provides what the body produces naturally (bio-identical DHEA) where we use it (in the skin).

(Labrie F, Belanger A, Belanger P, Berube R, Martel C, Cusan L, Gomez J, Candas B, et al. Metabolism of DHEA in Postmenopausal women following percutaneous administration. Journal of Steroid Biochemistry & Molecular Biology, 103 (Feb 2007) pp 178-188) www.ncbi.nlm.nih.gov/pubmed/17084625

(Labrie F, Belanger A, Cusan L, Candas L intraPhysiological Changes in Dehydroepiandrosterone Are Not Reflected by Serum Levels of Active Androgens and Estrogens But Their Metabolites: Intracrinology. Journal of Clinical Endocrinology and Metabolism. Vol. 82 No. 8, pgs 2403-2409)http://press.endocrine.org/dol/pdf/10.1210/jcem.82.8.4161

(Labrie F, Labrie C. DHEA and intracrinology at menopause, a positive choice for evolution of the human species.) www.ncbi.nlm.nih.gov/pubmed/23126249

DHEA must be delivered to the body properly as a specially made DHEA cream – Twist 25.

To know DHEA supplementation is safe think it through logically. DHEA is a naturally occurring pro-hormone. It is the most abundant pro-hormone in the body. DHEA is a base building block for hormones we produce. 50 hormones use DHEA as a precursor. The body makes DHEA and pregnenalone from cholesterol.

Why would something the body produces be harmful. No medical research studies of DHEA have shown any dangerous or harmful effects.

The goal should be to maintain levels of DHEA as when we are at our healthiest, “in our prime”. Normal levels of DHEA at age 25 are about 350 micrograms for women and 550 micrograms for men. Each pump press of Twist 25 DHEA cream provides about 20 MG DHEA. So women age 35 and up would benefit from using at least 1-2 pump presses per day; and men 2-3 pump presses per day unless otherwise directed by your physician. Testing levels regularly with a blood spot test is recommended to ensure optimum levels are maintained.

Go to www.twist25.com to learn more or http://store.twist25.com to order on line.

I am not compensated in any way for sales of Twist 25 cream. Please see my websites at www.abouthormones.org and dheafacts.com for my advice about current medical science.